Site-specific growth of Nocardia asteroides in the murine brain
نویسندگان
چکیده
منابع مشابه
Ultrastructural analysis of growth of Nocardia asteroides during invasion of the murine brain.
BALB/c mice were infected with 10(6) CFU of log-phase cells of Nocardia asteroides GUH-2 by tail vein injection (at this lethal inoculum dose, approximately 800 to 1,000 CFU becomes deposited in the brain). At 24 h after infection, the ultrastructural interactions of the nocardiae during growth within the murine brain were investigated. The nocardiae grew perivascularly in the pons, substantia ...
متن کاملInteractions of Nocardia asteroides with murine glia cells in culture.
Astrocytes and microglia were obtained from brains of newborn mice and infected with Nocardia asteroides. Scanning electron micrographs showed nocardiae adhering to the astrocyte cell surface and entering the cytoplasm. After 6 h of incubation the intracellular nocardiae appeared as filaments, demonstrating that growth was occurring. In contrast, the microglia phagocytized nocardiae, but after ...
متن کاملNocardia asteroides osteomyelitis.
Nocardia asteroides osteomyelitis has previously been described only in acutely ill patients. It may occur as an isolated event or part of the disease spectrum of disseminated nocardiosis. An 84 year old immune competent man with N. asteroides right tibial osteomyelitis had an unusual presentation, presumed mechanism of disease and outcome. His course affords an opportunity to review the litera...
متن کاملNocardia asteroides ocular infection
Methods The ocular samples viz., corneal swab, corneal scraping, aqueous tap and vitreous tap were processed for culture and the isolated Nocardia species were further confirmed for speciation by standard microbiological procedures. Antibiotic susceptibility analysis for the confirmed isolates of N. asteroides was performed by agar disk diffusion method following the guidelines of Clinical Labo...
متن کامل[Nocardia asteroides keratitis].
Problems in management of ulcerative keratitis may arise from delays in diagnosis and from inadequate response to treatment. In the present case, a corneal injury was followed by Nocardia asteroides keratitis. The organism isolated was sensitive in vitro to both sulphonamides and penicillin, but there was no satisfactory clinical improvement with sulphonamides alone. Good response to treatment ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1992
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.60.8.3262-3267.1992